Amphiphilic Zwitterionic Coating Copolymer
Poly(MPC-co-BMA)
Also known as PMB polymer, phospholipid polymer coating | MPC monomer CAS 67881-98-5 · BMA monomer CAS 97-88-1
An amphiphilic copolymer of MPC and n-butyl methacrylate (BMA) — the hydrophobic BMA segment anchors onto hydrophobic device substrates (polyurethane, PVC, polypropylene) by dip-coating, while the surface-exposed MPC layer suppresses protein adsorption and platelet activation. The reference chemistry behind decades of blood-contacting device coating research.
- Standard 30:70 MPC:BMA grade, custom ratios availableMPC:HEMA ratio, custom Mw available
MPC CAS 67881-98-5
MPC — BMA
Amphiphilic random copolymer
Appearance: White to off-white powder
Character: Amphiphilic, film-forming
Coating Method: Dip / spray coating
Storage: -20 °C, keep dry
ISO 9001:2015
Manufactured under certified quality management
Standard 30:70 Ratio
The most-cited MPC:BMA ratio in coating literature
Batch-Level COA
Ratio and Mw confirmation per lot
Sample to Bulk
1 g R&D vials up to multi-gram supply
MPC Monomer CAS
67881-98-5
BMA Monomer CAS
97-88-1
Character
Amphiphilic
Ref. Ratio
30 mol% MPC : 70% BMA
Package
1g / 10g / 100g
Anchors to the device, faces outward to the blood
Unlike our fully water-soluble MPC grades, PMB is built to stay put on a hydrophobic surface — that's what makes it a coating rather than a hydrogel.
Hydrophobic anchor
The BMA segment has strong affinity for hydrophobic device polymers (PU, PVC, PP), letting the coating physically entangle with and adhere to the substrate
Surface-exposed MPC layer
The zwitterionic MPC segment orients toward the aqueous/blood interface, suppressing protein adsorption and platelet activation.
Simple application
Applied by dip-coating or spray-coating from solution — no covalent grafting or surface pretreatment required for most substrates.
Decades of published data
Since Ishihara's original 1994 hemocompatibility work, PMB coatings have been studied across catheters, stents, membranes, and sutures.
Coating thickness, adhesion, and durability depend on substrate, solvent, and application method — our technical team can advise based on your device material.
Typical values for our standard grade. MPC:BMA ratio and molecular weight are configurable — request a batch-specific COA for your exact build.
| Synonyms | PMB polymer · MPC-BMA copolymer · Phospholipid polymer coating |
|---|---|
| MPC Monomer CAS | 67881-98-5 |
| BMA Monomer CAS | 97-88-1 |
| MPC Monomer Formula | C₁₁H₂₂NO₆P, MW 295.27 g/mol |
| BMA Monomer Formula | C₈H₁₄O₂, MW 142.20 g/mol |
| Copolymer Type | Random (statistical) copolymer, amphiphilic |
| Appearance | White to off-white powder |
| Reference MPC:BMA Ratio | 30 mol% : 70 mol% (most-cited literature grade) |
| MPC:BMA Ratio Range | Configurable — specify at order |
| Molecular Weight | Custom Mw available; specify at order |
| Solubility | Soluble in ethanol and other polar organic solvents for dip/spray coating |
| Storage Conditions | -20 °C, sealed, protected from moisture |
| Package Sizes | 1 g, 10 g, 100 g per bottle |
Choose your ratio by substrate and goal
More BMA improves film adhesion and durability; more MPC improves surface antifouling strength.
Higher BMA
Adhesion-dominant
30:70 MPC:BMA
Reference grade
Higher MPC
Antifouling-dominant
Applications
Vascular catheters & guidewires
Dip-coated onto polyurethane catheter surfaces to reduce friction and thrombogenicity.
Stents & heart valves
Studied extensively as a hemocompatible coating for neurovascular and cardiovascular implants.
Hollow-fiber blood membranes
Coats dialysis and blood-purification membranes to improve permeability and reduce protein fouling.
Ion-selective electrode coatings
Improves blood compatibility of PU- and PVC-based ISE membranes without affecting sensor response.
Antibacterial suture coatings
Reduces bacterial adhesion and biofilm formation on absorbable suture surfaces.
Nanoparticle & gene-delivery coatings
Amphiphilic self-assembly around nanoparticles helps avoid macrophage uptake in delivery studies.
Extracorporeal circuit tubing
Reduces platelet adhesion and activation on tubing surfaces during extended blood contact.
General implant surface modification
Broadly applicable coating for reducing foreign-body and inflammatory response on implanted devices.
Data & safety documents
Batch-specific COAs confirm MPC:BMA ratio and molecular weight. Contact us for a particular lot number.
Safety Data Sheet
GHS-format · EN / ZH
Certificate of Analysis
Ratio + Mw confirmation
¹H-NMR Spectrum
Structure confirmation
FAQ
Most frequent questions and answers
No — as a random copolymer with a configurable monomer ratio, it doesn’t have one universal CAS Registry Number. It’s identified by catalog number, with the monomer CAS numbers (MPC 67881-98-5, BMA 97-88-1) provided for reference.
Those grades are water-soluble and mainly used as hydrogels, pH-responsive carriers, or brush coatings on their own. Poly(MPC-co-BMA) is amphiphilic and designed to be dip- or spray-coated onto an existing hydrophobic device surface, where the BMA segment anchors the film in place.
It’s been studied on polyurethane, PVC, polypropylene, and polymethylpentene device surfaces, among others. Adhesion strength depends on substrate hydrophobicity and coating method — tell us your device material and we can advise.
30 mol% MPC to 70 mol% BMA is the most widely cited ratio in published hemocompatibility studies, and is our default standard grade. Custom ratios are available — higher BMA improves film adhesion, higher MPC improves antifouling strength.
Most protocols dissolve the polymer in ethanol or another polar organic solvent, then dip-coat or spray-coat the device, followed by air- or vacuum-drying. Coating thickness (commonly reported around 1–3 microns) depends on solution concentration and number of coating cycles.