Poly(L-lactide-co-D,L-lactide)
Synonyms: Poly-L-co-D,L-lactic acid (PLDLA).
Linear Formula: (C6H8O4)m(C6H8O4)n
Appearance: off-white to light yellow particle
Ratio(L-LA: DL-LA): 50:50/75:25/85:15/65:35
Minimal order quantity: 30 gram
PLDLA (Poly-L-lactide-co-DL-lactide) is a biodegradable and biocompatible copolymer widely recognized for its unique combination of properties that make it suitable for various biomedical applications. The polymer is composed of L-lactide and DL-lactide in specific ratios, typically available in 75:25, 85:15, or 50:50 formulations, which determine its mechanical properties and degradation rate. PLDLA’s viscosity can be tailored according to the specific needs of your application, offering flexibility in processing and performance. With its semi-crystalline nature and controlled degradation time, PLDLA is an ideal material for applications requiring gradual absorption and sustained mechanical support.
PLDLA polymers are extensively used in the medical field, particularly in the production of bioresorbable sutures, orthopedic implants, and drug delivery systems. Its ability to degrade into lactic acid, a naturally occurring substance in the human body, ensures minimal inflammatory response and safe absorption over time. Additionally, PLDLA’s customizable properties allow for its use in tissue engineering scaffolds, where it supports cell growth and tissue regeneration. Its versatility extends to the development of biodegradable stents, screws, and plates used in surgeries, contributing to reduced long-term complications and eliminating the need for secondary removal surgeries.
FAQ
Most frequent questions and answers
Yes, PLDLA can be used in 3D printing (FDM, SLA, and SLS) for biomedical applications, though processing conditions need to be optimized for thermal stability.
Higher L-lactide content: More crystalline, slower degradation, higher stiffness.
Higher D,L-lactide content: More amorphous, faster degradation, increased flexibility.
Degradation time varies but generally ranges from several months to a few years, depending on molecular weight, composition, and application.
Yes, by modifying the L-lactide/D,L-lactide ratio, molecular weight, and crystallinity, the degradation rate can be controlled.
The Tg of PLDLA typically falls between 50°C and 60°C, depending on molecular weight and composition.
PLDLA is soluble in common organic solvents such as dichloromethane (DCM), chloroform, acetone, and ethyl acetate, but it is insoluble in water.
PLDLA has moderate thermal stability, but prolonged exposure to high temperatures can cause degradation. The processing temperature should generally remain below 180°C to prevent degradation.
Yes, but the method depends on the application:
Ethylene oxide (EtO) sterilization: Common and effective.
Gamma irradiation: Possible but may cause molecular weight degradation.
Autoclaving (steam sterilization): Not recommended due to hydrolytic sensitivity.
Yes, PLDLA is commonly used in biodegradable microspheres and nanoparticles for sustained drug release. Its degradation rate can be tuned to match drug delivery requirements.