PLGA 75:25
Synonyms: Poly(DL-lactide-co-glycolide) 75:25
CAS No: 26780-50-7
Appearance: Pale yellow particle
End Group: Acid, Ester and Hydroxyl group for options
Minimal order quantity: 30 gram
PLGA 75:25 is a biodegradable polymer composed of 75% lactic acid and 25% glycolic acid. This specific ratio creates an optimal balance between strength and degradation time, making it a preferred choice for numerous biomedical applications.
The polymer breaks down naturally in the body through hydrolysis, typically degrading over a period of 4-6 months. This controlled degradation makes PLGA 75:25 particularly valuable for temporary implants and drug delivery systems where a medium-term presence is desired.
Medical researchers appreciate PLGA 75:25 for its excellent biocompatibility and minimal inflammatory response. When implanted, it gradually dissolves into lactic and glycolic acids, which are naturally metabolized and eliminated by the body without harmful byproducts.
The material offers good mechanical properties while maintaining processability through standard techniques. It has been successfully used in FDA-approved medical devices, sutures, and drug delivery systems, demonstrating its reliability and safety profile in clinical settings.
| Chemical Name | IV(dl/g) | Mw(Da) |
|---|---|---|
| 75/25 Poly(DL-lactide-co-glycolide) Acid, Ester and Hydroxyl group for options | ≤0.08 | ≤5000 |
| 75/25 Poly(DL-lactide-co-glycolide) Acid, Ester and Hydroxyl group for options | 0.08-0.18 | 5000-15,000 |
| 75/25 Poly(DL-lactide-co-glycolide) Acid, Ester and Hydroxyl group for options | 0.18-0.25 | 15,000-23,000 |
| 75/25 Poly(DL-lactide-co-glycolide) Acid, Ester and Hydroxyl group for options | 0.25-0.35 | 23,000-37,000 |
| 75/25 Poly(DL-lactide-co-glycolide) Acid, Ester and Hydroxyl group for options | 0.35-0.45 | 37,000-52,000 |
| 75/25 Poly(DL-lactide-co-glycolide) Acid, Ester and Hydroxyl group for options | 0.45-0.55 | 52,000-69,000 |
| 75/25 Poly(DL-lactide-co-glycolide) Acid, Ester and Hydroxyl group for options | 0.55-0.65 | 69,000-87,000 |
| 75/25 Poly(DL-lactide-co-glycolide) Acid, Ester and Hydroxyl group for options | 0.65-0.75 | 87,000-106,000 |
| 75/25 Poly(DL-lactide-co-glycolide) Acid, Ester and Hydroxyl group for options | 0.75-0.85 | 106,000-127,000 |
| 75/25 Poly(DL-lactide-co-glycolide) Acid, Ester and Hydroxyl group for options | 0.85-1.0 | 127,000-159,000 |
| 75/25 Poly(DL-lactide-co-glycolide) Acid, Ester and Hydroxyl group for options | 1.0-2.0 | 159,000-416,000 |
| 75/25 Poly(DL-lactide-co-glycolide) Acid, Ester and Hydroxyl group for options | 2.0-3.0 | 416,000-730,000 |
FAQ
Most frequent questions and answers
PLGA 75:25 typically degrades over a period of 4-6 months under physiological conditions. However, the exact degradation time can vary depending on factors such as molecular weight, processing conditions, and the environment in which it’s placed.
PLGA 75:25 can be processed using various techniques including solvent casting, extrusion, injection molding, electrospinning, and emulsion methods for particle formation. The choice of processing method depends on the desired final form and application.
The ratio in PLGA determines its degradation rate and mechanical properties. PLGA 75:25 degrades faster than PLGA with higher lactic acid content (like 85:15) but slower than those with higher glycolic acid content (like 50:50). This makes it suitable for medium-term applications.
Yes, but sterilization methods must be chosen carefully. Ethylene oxide and gamma irradiation are commonly used, though they may affect polymer properties. Steam sterilization is generally not recommended as the high temperature and moisture can cause significant degradation.
The molecular weight is determined during synthesis and can be controlled by factors such as reaction time, temperature, catalyst concentration, and monomer purity. Different molecular weights offer varying degradation rates and mechanical properties.
No, PLGA 75:25 is not water-soluble. It’s typically dissolved in organic solvents such as dichloromethane, chloroform, acetone, or ethyl acetate for processing. This hydrophobic nature contributes to its controlled degradation profile in biological environments.