Polydioxanone
Synonyms: PPDO, PDO, Poly (p-dioxanone), PDS
CAS No: 31621-87-1
Appearance: White particle
Range of Viscolity: 0.2-4.5 dl/g
Minimal order quantity: 30 gram
Polydioxanone (PDO) is a synthetic, biodegradable polymer known for its flexibility and strength. It is produced through the ring-opening polymerization of p-dioxanone, resulting in a colorless, crystalline material.
One of the primary applications of polydioxanone is in the medical field, especially for manufacturing absorbable surgical sutures. These sutures maintain approximately 70% of their tensile strength after two weeks and provide wound support for about 60 days. Complete absorption of the material occurs between 180 to 240 days, minimizing the need for suture removal and reducing patient discomfort.
Beyond sutures, polydioxanone is utilized in various biomedical applications, including orthopedics, maxillofacial surgery, plastic surgery, drug delivery systems, cardiovascular devices, and tissue engineering. Its degradation products are primarily excreted through urine, with the remainder eliminated via the digestive system or as carbon dioxide. The material is fully reabsorbed within six months, eliciting minimal tissue reaction, which underscores its biocompatibility and suitability for medical use.
| Test Items | Standards |
|---|---|
| Appearance | White to light brown solid |
| Intrinsic viscosity（dL/g） | 1.8-2.2 |
| Melting point(℃) | 100-120 |
| Solvent residue(%) | <1 |
| Water residue(%) | ≤0.5 |
| Monomer residue(%) | ≤1 |
| Water residue(ppm) | ＜100 |
| Total heavy metal content (ppm) | ≤10 |
| Tin Residue(ppm) | ≤100 |
FAQ
Most frequent questions and answers
The molecular weight range of Polydioxanone (PDO) can vary depending on the specific application and manufacturing process. Common molecular weight ranges for PDO typically fall between 10,000 Da to 100,000 Da.
The polydispersity index (PDI) of Polydioxanone (PDO) typically falls in the range of 1.5 to 2.5 for most commercial grades.
The purity level of Polydioxanone (PDO) typically ranges from 98% to 99.9% for high-quality grades, especially those intended for medical or pharmaceutical applications. The residual monomer content, which refers to any unreacted p-dioxanone monomers in the polymer, is generally kept very low to ensure the safety and biocompatibility of the material.
The typical degradation timeframe for Polydioxanone (PDO) in biological environments generally ranges from 6 months to 12 months, depending on factors like the specific product form (e.g., sutures or implants), the local tissue environment, and the molecular weight of the PDO used.
The crystallinity of Polydioxanone (PDO) typically ranges between 30% and 40% for most commercial grades. Crystallinity in PDO influences its mechanical properties, such as strength and rigidity, as well as its degradation rate.
Polydioxanone (PDO) is soluble in a variety of organic solvents, but the compatibility depends on factors like temperature and the molecular weight of the polymer. Common solvents that are compatible with PDO include:
Chloroform – A widely used solvent for PDO, especially in solutions for processing into films, fibers, or coatings.
Dichloromethane (DCM) – Another effective solvent, often used in combination with other solvents for PDO processing.
Tetrahydrofuran (THF) – Suitable for dissolving PDO, especially for fabrication into various polymer forms.
Acetone – PDO can dissolve in acetone at elevated temperatures, though it is often combined with other solvents for better solubility.
Dimethylformamide (DMF) – A solvent that can dissolve PDO at higher temperatures.
Dimethyl sulfoxide (DMSO) – Occasionally used to dissolve PDO, especially in controlled processing environments.
The melting point of Polydioxanone (PDO) is typically around 180°C to 220°C, depending on its molecular weight and crystallinity.
The storage stability and shelf life of Polydioxanone (PDO) depend on several factors, including storage conditions, packaging, and the presence of any residual moisture or solvents. However, in general:
Storage Stability: PDO is relatively stable when stored in cool, dry, and controlled conditions. It should be kept away from direct sunlight, humidity, and extreme temperatures to maintain its properties over time. If the material is exposed to high temperatures or moisture, it may experience hydrolytic degradation, which could reduce its performance.
Shelf Life: The typical shelf life for PDO is 2 to 3 years when stored in optimal conditions. To maximize shelf life, PDO should be stored in airtight, moisture-proof packaging and kept at temperatures below 25°C (77°F). It’s crucial to avoid exposure to excessive humidity, as moisture can accelerate the degradation process.