mPEG-PCL
Synonyms: Methoxypoly(ethylene glycol)-poly caprolactone, mPEG-PCL
Appearance: Pale yellow particle
mPEG Type: 500, 1000, 2000, 4000
Minimal order quantity: 30 gram
Methoxy poly(ethylene glycol)-b-poly(ε-caprolactone), commonly referred to as mPEG-PCL, is a copolymer recognized for its amphiphilic nature, attributed to its two main constituents: methoxy poly(ethylene glycol) (mPEG) and poly(ε-caprolactone) (PCL). Each of these components brings specific attributes to the copolymer, allowing it to be versatile and highly useful, particularly in biomedical and pharmaceutical applications.
The hydrophilic mPEG segment of the copolymer ensures solubility in water and compatibility with biological environments. It contributes to the stealth characteristics of the copolymer, allowing it to evade immune responses and circulate within biological systems effectively, a characteristic particularly important in drug delivery applications.
Contrarily, the PCL portion is hydrophobic and contributes to the structural integrity of the copolymer, allowing for the encapsulation of various hydrophobic drug molecules. This is significant in pharmaceutical applications where protecting the drug from premature degradation and ensuring its controlled release are crucial.
One noteworthy application of mPEG-PCL is in the formulation of drug delivery nanoparticles or micelles. These structures are capable of carrying therapeutic agents directly to specific sites, minimizing systemic side effects and enhancing the therapeutic efficacy of the drugs. This is especially pertinent in cancer therapy, where targeted drug delivery is essential to spare healthy cells and tissues from the cytotoxic effects of anticancer drugs.
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