PolyDL-lactide-co-glycolide

Poly(dl-lactide-co-glycolide)

Synonyms: PDLGA

CAS No: 26780-50-7

Ratio:5050/7525/8515/6535

Appearance: White or light yellow powder

End Group: Acid, Ester and Hydroxyl group for options

Minimal order quantity: 30 gram

Are you looking for a biodegradable and biocompatible polymer that can be used for various medical applications? Do you want to customize the molecular weight, end group and ratio of your polymer to suit your specific needs? If so, you need Poly(DL-lactide-co-glycolide)!

Poly(DL-lactide-co-glycolide), or PLGA, is a copolymer of lactic acid and glycolic acid that can be synthesized by ring-opening polymerization. It has a wide range of applications in drug delivery, tissue engineering, bone repair, and surgical sutures. It can also degrade in the body by hydrolysis, producing harmless by-products that are metabolized or excreted.

Poly(DL-lactide-co-glycolide) is not only versatile, but also customizable. You can choose the molecular weight, end group and ratio of your polymer to control its properties, such as crystallinity, mechanical strength, degradation rate, and drug release profile. Whether you need a low molecular weight polymer with free carboxylic acid end groups and a 50:50 ratio for fast degradation and drug release, or a high molecular weight polymer with ester end groups and a 75:25 ratio for slow degradation and drug delivery, we have it all!

Poly(DL-lactide-co-glycolide) is also easy to use and cost-effective. It can be dissolved in various organic solvents, such as methylene chloride, tetrahydrofuran, ethyl acetate, acetone, chloroform, and hexafluoroisopropanol. It can also be processed by different methods, such as solvent casting, spray drying, emulsion, extrusion, and injection molding.

Don’t wait any longer to get your hands on Poly(DL-lactide-co-glycolide), the ultimate polymer for your medical needs. Order now and enjoy our fast delivery and competitive prices. Poly(DL-lactide-co-glycolide) is in high demand and limited supply, so act fast before it runs out!

FAQs

PLGA (Poly(lactic-co-glycolic acid)) is a biodegradable and biocompatible polymer that is commonly used in the medical field. It is used for a variety of applications such as drug delivery systems, tissue engineering, and medical implants. 

PLGA is particularly effective in controlled release of drugs as it can be modified to degrade at a specific rate, allowing for the sustained release of medication over a desired period of time. Additionally, PLGA is also used in surgical sutures as it offers excellent strength and biodegradability.

The main side effect of PLGA (Poly(lactic-co-glycolic acid)) polymer is its potential for causing an inflammatory response. This can lead to local tissue reactions such as redness, swelling, and pain at the site of implantation. 

Additionally, PLGA can degrade into lactic acid and glycolic acid, which at high levels can potentially cause acidosis and disrupt the pH balance in the body. Other possible side effects of PLGA include allergic reactions, tissue damage, and infection, although these are relatively rare.

PLGA (Poly(lactic-co-glycolic acid)) polymer is generally considered to be biocompatible and non-toxic when used in biomedical applications.

The best solvent for PLGA (Poly(lactic-co-glycolic acid)) depends on the specific application and the desired properties of the solution. However, common solvents used for PLGA include dichloromethane (DCM), ethyl acetate, and chloroform.

The main difference between PLA (polylactic acid) and PLGA (polylactic-co-glycolic acid) lies in their chemical composition. PLA is a biodegradable polymer made from lactic acid, while PLGA is a copolymer composed of dl-lactide and glycolide.

The presence of the glycolic acid in PLGA gives it different properties compared to PLA, such as increased hydrophilicity and faster degradation rates. This distinction is important when considering their various applications, as PLA is commonly used in packaging, 3D printing, and medical implants, while PLGA finds extensive use in drug delivery systems and tissue engineering.

No, PLGA (poly(lactic-co-glycolic acid)) is not a natural polymer. It is a synthetic polymer derived from the combination of lactic acid and glycolic acid.

No, PLGA (poly(lactic-co-glycolic acid)) is not a hydrogel. It is a biodegradable and biocompatible polymer that is commonly used in drug delivery systems and tissue engineering due to its controlled release properties. However, hydrogels are a different class of materials that are composed of water-swollen polymeric networks.

PLGA (Poly(lactic-co-glycolic acid)) can have different levels of transparency depending on its composition and processing. It can range from transparent to opaque.

PLGA (Polylactic-co-glycolic acid) can be amorphous because of its molecular structure and composition. It is a copolymer made up of lactic acid and glycolic acid units, which are both hydrophilic in nature. The random arrangement of these units within the polymer chain and the absence of regular crystalline regions contribute to the amorphous nature of PLGA.

Additionally, the rapid cooling or quenching process during PLGA synthesis or fabrication can also result in an amorphous structure.

Yes, PLGA is a mucoadhesive material. It is commonly used in drug delivery systems to enhance the attachment and retention of the drug at mucosal surfaces. Its mucoadhesive properties allow for prolonged drug release and better therapeutic efficacy.

Yes, PLGA (poly(lactic-co-glycolic acid)) is known to be biodegradable and soluble in water. It dissolves in water through a process called hydrolysis, where the ester linkages in PLGA break down, leading to the release of its constituents, lactic acid and glycolic acid.

Yes, PLGA polymer is FDA-approved. It has been extensively studied and recognized for its safety and biocompatibility, making it a commonly used material in various medical applications.

PLGA (poly(lactic-co-glycolic acid)) itself is not inherently antimicrobial. However, PLGA can be functionalized or modified to incorporate antimicrobial agents or compounds to impart antimicrobial properties. 

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