Poly(DL-lactide-co-glycolide)/PLGA
Synonyms: PLGA
CAS No: 26780-50-7
Ratio:5050/7525/8515/6535
Appearance: White or light yellow powder
End Group: Acid, Ester and Hydroxyl group for options
Minimal order quantity: 30 gram
Poly(lactic-co-glycolic-acid), which is also called PLGA or PLG, is a copolymer used in a variety of FDA-approved therapeutic devices. The main features include high biodegradability and biocompatibility, making it one of the most used synthetic devices for drug delivery and various tissue engineering applications.
PLGA is a copolymer formed from polylactic acid (PLA) and polyglycolic acid (PGA). Extensive studies have examined the biodegradability of PLGA. It features the characteristics needed for sustained drug delivery, including increased strength and slower degradation compared to PGA and PLA polymers.
The primary uses for poly(lactic-co-glycolic-acid)/PLGA include drug delivery, body tissue engineering, and additional biomedical applications. It is approved by the FDA and frequently used in clinical and basic scientific research, including research into cancer and cardiovascular disease.
FAQs
PLGA (Poly(lactic-co-glycolic acid)) is a biodegradable and biocompatible polymer that is commonly used in the medical field. It is used for a variety of applications such as drug delivery systems, tissue engineering, and medical implants.
PLGA is particularly effective in controlled release of drugs as it can be modified to degrade at a specific rate, allowing for the sustained release of medication over a desired period of time. Additionally, PLGA is also used in surgical sutures as it offers excellent strength and biodegradability.
The main side effect of PLGA (Poly(lactic-co-glycolic acid)) polymer is its potential for causing an inflammatory response. This can lead to local tissue reactions such as redness, swelling, and pain at the site of implantation.
Additionally, PLGA can degrade into lactic acid and glycolic acid, which at high levels can potentially cause acidosis and disrupt the pH balance in the body. Other possible side effects of PLGA include allergic reactions, tissue damage, and infection, although these are relatively rare.
PLGA (Poly(lactic-co-glycolic acid)) polymer is generally considered to be biocompatible and non-toxic when used in biomedical applications.
The best solvent for PLGA (Poly(lactic-co-glycolic acid)) depends on the specific application and the desired properties of the solution. However, common solvents used for PLGA include dichloromethane (DCM), ethyl acetate, and chloroform.
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