Synonyms: Poly(D,L-lactide)-PEG-methyl ether , Mpeg-PDLLA

MPEG Type: 500, 1000, 2000, 4000

PDLLA Mw: 2,000 – 500,000 Da

Minimal order quantity: 10 gram

Mpeg-PDLLA, or methoxy poly(ethylene glycol)-b-poly(D,L-lactide), is a block copolymer known for its unique attributes and versatile applications, particularly in the pharmaceutical and biomedical fields. This copolymer comprises two distinct segments: methoxy poly(ethylene glycol) (Mpeg), a hydrophilic segment, and poly(D,L-lactide) (PDLLA), a hydrophobic segment. Together, these segments give Mpeg-PDLLA amphiphilic properties, making it an excellent candidate for drug delivery systems and other biomedical applications.

The hydrophilic Mpeg segment improves the copolymer’s water solubility and biocompatibility, ensuring that it interacts favorably with biological systems. This feature is particularly advantageous in drug delivery, as it allows for enhanced circulation times and improved biodistribution of therapeutic agents. On the other hand, the hydrophobic PDLLA segment facilitates the encapsulation of a wide variety of drug molecules, protecting them from degradation and enabling controlled release.

Mpeg-PDLLA has been instrumental in the formulation of nanoparticles and micelles for drug delivery. These nanostructures can efficiently encapsulate and transport both hydrophilic and hydrophobic drugs, offering targeted and sustained release profiles. This is crucial for improving the therapeutic efficacy and reducing the side effects of various medications.

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