Zwitterionic Brush Copolymer · Dual Antifouling
Poly(MPC-co-PEGMA)
Also listed as Poly(PEGMA-co-MPC) | MPC monomer CAS 67881-98-5 · PEGMA monomer CAS 26915-72-0
A copolymer of MPC and poly(ethylene glycol) methacrylate (PEGMA) that stacks two independently proven antifouling mechanisms on one backbone: MPC’s zwitterionic hydration layer and PEGMA’s PEG-brush steric shielding. Built for surfaces that need maximum resistance to protein, cell, and biofilm adhesion.
- Configurable MPC:PEGMA ratio, custom PEG side-chain length
MPC CAS 67881-98-5
MPC — PEGMA
Random copolymer, brush architecture
Appearance: White to off-white powder
Character: Zwitterionic + PEG-brush
Mechanism Dual antifouling
Storage: -20 °C, dark, desiccated
ISO 9001:2015
Manufactured under certified quality management
Custom MPC:PEGMA Ratio
PEG side-chain length (n) also configurable
Batch-Level COA
Ratio and Mw confirmation per lot
Sample to Bulk
1 g R&D vials up to multi-gram supply
MPC Monomer CAS
67881-98-5
PEGMA Monomer CAS
26915-72-0
Architecture
Brush copolymer
Mechanism
Zwitterionic + steric
Package
1g / 10g / 100g
Two antifouling mechanisms, one backbone
MPC and PEGMA are two of the most studied antifouling technologies in biomaterials research — usually compared as competitors. Here they work together.
MPC — zwitterionic hydration
- Phosphorylcholine head binds a tight water layer at the surface
- Resists a broad range of proteins and cell types
- Stable in aqueous and physiological environments
PEGMA — steric brush shielding
- PEG side chains physically block protein approach to the surface
- Adds hydration and lubricity at the interface
- Well-characterized, widely used "gold standard" hydrophilic brush
Bar length is illustrative, not a measured performance ranking — actual antifouling performance depends on grafting density, chain length, and your specific surface. Combining both mechanisms is reported to outperform either alone in surface studies.
Typical values for our standard grade. MPC:PEGMA ratio, PEG side-chain length, and molecular weight are configurable.
Synonyms | Poly(PEGMA-co-MPC) · MPC-PEGMA copolymer · Zwitterionic PEG-brush copolymer |
|---|---|
| MPC Monomer CAS | 67881-98-5 |
| PEGMA Monomer CAS | 26915-72-0 (methoxy-capped, standard grade) |
| MPC Monomer Formula | C₁₁H₂₂NO₆P, MW 295.27 g/mol |
| PEG Side-Chain Length | Average Mn 300 – 950 g/mol, selectable |
| Copolymer Type | Random (statistical) copolymer, comb/brush architecture |
| Appearance | White to off-white powder |
| Character | Zwitterionic (MPC) + nonionic hydrophilic brush (PEGMA) |
| End Group (PEG side chain) | Methoxy-capped (standard); non-capped -OH grades available on request |
| MPC:PEGMA Ratio | Configurable — specify at order |
| Molecular Weight | Custom Mw available; specify at order |
| Solubility | Water-soluble |
| Storage Conditions | -20 °C, sealed, protected from moisture |
| Package Sizes | 1 g, 10 g, 100 g per bottle |
Need a specific PEG side-chain length or a non-capped -OH grade for further conjugation? Talk to technical sales →
Choose your ratio by surface goal
Shifting the ratio shifts which mechanism dominates the surface behavior.
MPC-dominant
Charge-based emphasis
Stronger zwitterionic hydration character, more like our pMPC and MPC-HEMA grades.
Balanced
Dual-mechanism grade
Standard grade for most antifouling and lubricious coating applications.
PEGMA-dominant
Steric-brush emphasis
Thicker PEG brush layer — favors maximum lubricity and steric shielding.
Applications
Lubricious catheter & guidewire coatings
PEG-brush lubricity combined with MPC's biocompatible surface for reduced insertion friction.
Marine antifouling coatings
Resists bacterial, algal, and larval settlement on submerged surfaces — an area where both MPC and PEGMA brushes are independently established.
Orthopedic bearing surfaces
Surface modification of crosslinked polyethylene liners to reduce wear-related and inflammatory response.
Stealth drug-carrier surfaces
Dual-mechanism shielding for nanoparticle and micelle surfaces designed for extended circulation.
Contact lens & ophthalmic surfaces
Enhanced wettability and lubricity for extended-wear comfort.
Surface-initiated polymer brushes
Used as a monomer feed for SI-ATRP grafting to build antifouling brush layers directly from a substrate.
Biosensor background reduction
Dual-mechanism coating minimizes nonspecific binding for cleaner assay signal.
Wound care & hydrogel dressings
Highly hydrated, low-adhesion surface that doesn't stick to healing tissue.
Data & safety documents
Batch-specific COAs confirm MPC:PEGMA ratio and molecular weight. Contact us for a particular lot number.
Safety Data Sheet
GHS-format · EN / ZH
Certificate of Analysis
Ratio + Mw confirmation
¹H-NMR Spectrum
Structure confirmation
FAQ
Most frequent questions and answers
No — as a random copolymer with a configurable monomer ratio, it doesn’t have one universal CAS Registry Number. It’s identified by catalog number, with the monomer CAS numbers (MPC 67881-98-5, PEGMA 26915-72-0) provided for reference.
MPC and PEGMA resist protein and cell adhesion through different physical mechanisms — MPC through zwitterionic hydration, PEGMA through steric brush shielding. Surface studies have found the combination outperforms either mechanism alone, since fouling species that partially evade one mechanism are still blocked by the other.
HEMA adds neutral hydrogel structure, MAA adds pH-responsive charge and a -COOH conjugation handle, and PEGMA adds a PEG brush layer for maximum antifouling and lubricity. Choose PEGMA when surface lubricity and dual-mechanism fouling resistance matter more than a reactive conjugation site.
The standard grade uses methoxy-capped PEGMA, which has no reactive end group on the PEG side chain. If you need a conjugation handle, ask about our non-capped (-OH terminated) PEGMA grade, or consider our Poly(MPC-co-MAA) grade instead.
It’s the molecular weight of the pendant PEG chain hanging off each PEGMA unit (commonly Mn 300–950 g/mol). Longer side chains generally increase brush thickness and lubricity but can reduce grafting density — the right length depends on your substrate and application.
Store at -20°C, sealed, and protected from moisture. Once in aqueous solution, avoid repeated freeze-thaw cycles, which can affect reproducibility of coating performance.