PLA-PEG-FITC
Fluorescein-labeled PLA-PEG diblock copolymer | PLA block · PEG block · FITC tag
A hydrophobic PLA block joined to a hydrophilic PEG block, with FITC attached at the PEG terminus. Self-assembles into micelles and nanoparticles in water — built to visualize PEGylated, “stealth” drug-delivery systems designed for long blood circulation.
- Configurable PLA stereochemistry & PEG block length
PEG CAS 25322-68-3
PLA — PEG — FITC
Diblock copolymer, PEG-terminus labeled
Appearance: Pale yellow-green solid/wax
Assembly: Micelles in water
Label Site: PEG terminus
Storage: -20 °C, dark, desiccated
ISO 9001:2015
Manufactured under certified quality management
Custom Block Ratios
PLA and PEG block lengths configurable to spec
Batch-Level COA
Block Mw, PDI and free-dye content per lot
Light-Safe Shipping
Amber, insulated packaging protects fluorescence
Copolymer Type
Diblock, amphiphilic
Excitation / Emission
495 / 519 nm
Self-Assembly
Micelle / NP
Circulation
Extended (PEGylated)
MOQ
1 g
Fluorescence & self-assembly parameters
Beyond the standard fluorescence data, block copolymers add one more question researchers ask first: does it self-assemble the way you need it to?
Excitation / Emission
Ex ≈ 495 nm / Em ≈ 519 nm — standard FITC spectral profile, compatible with FITC/GFP filter sets and channels.
Critical micelle concentration
Self-assembles above its CMC into core-shell micelles — exact CMC depends on block ratio; reported on the batch COA.
Label position
FITC sits at the PEG terminus, away from the hydrophobic PLA core, keeping the label at the micelle surface for reliable detection.
Photostability
Standard FITC photobleaching kinetics apply — minimize light exposure during handling and imaging.
Exact quantum yield and per-batch spectral scans are provided with the Certificate of Analysis — see Documents below.
Typical values for our standard grade. PLA stereochemistry and PEG block length are configurable — request a batch-specific COA for your exact build.
PEG Block CAS | 25322-68-3 (polyethylene glycol) |
|---|---|
| Label | Fluorescein isothiocyanate, CAS 27072-45-3 |
| Conjugation Site | PEG terminus (amine-PEG), thiourea linkage |
| PLA Block | PLLA, PDLA, or PDLLA — selectable stereochemistry |
| PEG Block Mw | 1,000 – 5,000 g/mol (common range, customizable) |
| PLA Block Mw | 2,000 – 20,000 g/mol (common range, customizable) |
| Appearance | Pale yellow-green solid or waxy powder |
| Excitation / Emission | ≈ 495 nm / ≈ 519 nm |
| Self-Assembly | Forms core-shell micelles/nanoparticles above CMC in aqueous media |
| Solubility | Amphiphilic — disperses in water, soluble in chloroform, DMSO |
| Storage Conditions | -20 °C, sealed, desiccated, protected from light |
| Minimal Order Quantity | 1 g |
Need figures outside this range, or a certificate for a specific lot? Talk to technical sales →
Choose your PLA:PEG balance
The PLA:PEG ratio controls particle size, circulation time, and how tightly the micelle core holds a hydrophobic payload.
PEG-rich
Higher PEG fraction
Smaller, more hydrophilic particles — longest circulation, lowest payload capacity.
Balanced
Standard grade
Default block ratio for most stealth-nanoparticle and micelle-tracking studies.
PLA-rich
Higher PLA fraction
Larger, denser hydrophobic core — higher payload capacity, shorter circulation.
Applications
Stealth nanoparticle tracking
Visualize PEGylated nanoparticle circulation and clearance in long-timeline in vivo biodistribution studies.
Micelle self-assembly studies
Confirm micelle formation and core-shell structure by fluorescence microscopy or dynamic light scattering.
PEGylation confirmation
Verify surface PEG coverage and reduced protein adsorption relative to unPEGylated PLA particles.
Reduced RES uptake studies
Compare immune-system clearance of PEGylated versus non-PEGylated PLA nanoparticles.
FAQ
Most frequent questions and answers
Because PLA-PEG self-assembles with PEG facing outward (the hydrophilic shell) and PLA forming the hydrophobic core, labeling the PEG terminus keeps the fluorophore at the particle surface — more accessible for detection and less likely to disrupt core drug loading.
The PEG shell reduces protein adsorption and recognition by the immune system, extending circulation time in the bloodstream compared to plain PLA nanoparticles — this is the basis of “stealth” drug-delivery design.
PEG itself is not biodegradable in the same hydrolytic sense as PLA — it’s typically cleared renally once released as the PLA core degrades and the block copolymer structure breaks down.
Yes — the PLA block can be built from PLLA, PDLA, or PDLLA depending on the degradation timeline you need. Specify your preferred stereochemistry when requesting a quote.