Fluorescent Amorphous Polylactide
FITC-PDLLA
Fluorescein-labeled Poly(DL-lactide) | Base polymer CAS 51056-13-9
FITC covalently conjugated to amorphous Poly(DL-lactide) — a fast-clearing fluorescent tracer suited to shorter experimental windows, ideal for nanoparticle and microsphere biodistribution studies.
- Multiple IV/Mw grades & end-group options, MOQ 1 g
Base CAS 51056-13-9
PDLLA — FITC
Fluorescein-labeled Poly(DL-lactide)
Appearance: Pale yellow-green powder
Structure: Amorphous, no Tm
Glass Transition: ≈ 40–60 °C
Storage: -20 °C, dark, desiccated
ISO 9001:2015
Manufactured under certified quality management
Verified Labeling
UV-Vis confirmed degree of labeling per batch
Batch-Level COA
Spectral data and free-dye content per lot
Light-Safe Shipping
Amber, insulated packaging protects fluorescence
Base Polymer CAS
51056-13-9
Excitation / Emission
495 / 519 nm
Structure
Amorphous
Degradation
Fast (days–weeks)s)
MOQ
1 g
Fluorescence parameters
These values are what most researchers check first — they determine whether this label works with your imaging setup and dosing.
Excitation / Emission
Ex ≈ 495 nm / Em ≈ 519 nm — standard FITC spectral profile, compatible with FITC/GFP filter sets and channels.
Degree of labeling
Typically 0.5–3 mol% FITC per polymer chain, grade-dependent. Custom labeling density available on request.
Free-dye removal
Purified by dialysis to remove unconjugated FITC — each COA reports residual free-dye content by UV-Vis.
Photostability
Standard FITC photobleaching kinetics apply — minimize light exposure during handling and imaging.
Exact quantum yield and per-batch spectral scans are provided with the Certificate of Analysis — see Documents below.
Base-polymer values for our standard PDLLA grade. Request a batch-specific COA for labeling degree and spectral data on your order.
Base Polymer CAS | 51056-13-9 (unlabeled PDLLA) |
|---|---|
| Label | Fluorescein isothiocyanate, CAS 27072-45-3 |
| Conjugation Site | Chain-end amine, thiourea linkage |
| Appearance | Pale yellow-green powder |
| Structure | Amorphous — racemic D/L backbone, no melting point |
| Glass Transition (Tg) | ≈ 40–60 °C, grade-dependent |
| Excitation / Emission | ≈ 495 nm / ≈ 519 nm |
| Degree of Labeling | 0.5–3 mol% FITC per chain, grade-dependent |
| Solubility | Soluble in chloroform, THF, acetone; insoluble in water |
| Storage Conditions | -20 °C, sealed, desiccated, protected from light |
| Minimal Order Quantity | 1 g |
Need figures outside this range, or a certificate for a specific lot? Talk to technical sales →
Choose a grade by degradation timeline
Higher IV/Mw grades degrade more slowly, extending the window over which fluorescence signal reflects intact polymer.
0.1–0.3 dl/g
Low IV
Mw ≈ 5,000–15,000. Fastest clearance — short-window microsphere and uptake studies.
0.3–1.0 dl/g
Mid IV
Mw ≈ 20,000–80,000. General-purpose grade for most nanoparticle tracking work.
1.0–2.5 dl/g
High IV
Mw ≈ 80,000–200,000. Extended signal window for multi-week studies.
Applications
Nanoparticle biodistribution
Fast, uniform degradation makes this the standard label for tracking PLA nanoparticle clearance in vivo.
Microsphere imaging
Visualize drug-loaded PDLLA microsphere uptake and release alongside the active ingredient.
Cell uptake assays
Quantify short-timeline cellular internalization of PDLLA-based particles by confocal microscopy or flow cytometry.
Anti-adhesion barrier tracking
Confirm coverage and clearance of resorbable PDLLA surgical barriers over their short functional window.
FAQ
Most frequent questions and answers
No — as a conjugate, it’s identified by catalog number rather than a single CAS Registry Number. The base Poly(DL-lactide) carries CAS 51056-13-9, and the FITC label carries CAS 27072-45-3.
PDLLA is amorphous and degrades faster and more uniformly than the semi-crystalline PLLA/PDLA grades, making it the better choice for shorter experiments — nanoparticle biodistribution, microsphere release, and cell uptake studies.
No — FITC is covalently bonded to the polymer chain end via a stable thiourea linkage, not physically adsorbed, so it doesn’t leach out during handling or in aqueous media.
Yes — we offer the same PDLLA backbone labeled with alternative fluorophores (e.g. Cy5, Cy7) for multi-channel or deeper-tissue imaging. Contact technical sales for available options.