FITC-PLLA
Fluorescein-labeled Poly(L-lactide) | Base polymer CAS 33135-50-1
FITC covalently conjugated to Poly(L-lactide) — a bright, non-leaching fluorescent tracer for long-timeline imaging of implants, scaffolds, and slow-degrading drug-delivery devices.
- Multiple IV/Mw grades & end-group options, MOQ 30 g
CAS 51056-13-9
PLLA — FITC
Fluorescein-labeled Poly(L-lactide)
Appearance: Pale yellow-green powder
Structure: Semi-crystalline
Melting Point: 170–180 °C (Tm)
Storage: -20 °C, dark, desiccated
ISO 9001:2015
Manufactured under certified quality management
Verified Labeling
UV-Vis confirmed degree of labeling per batch
Batch-Level COA
Spectral data and free-dye content per lot
Light-Safe Shipping
Amber, insulated packaging protects fluorescence
Base Polymer CAS
33135-50-1
Excitation / Emission
495 / 519 nm
Structure
Semi-crystalline
Degradation
Slow (months)
MOQ
1 g
Fluorescence parameters
These values are what most researchers check first — they determine whether this label works with your imaging setup and dosing.
Excitation / Emission
Ex ≈ 495 nm / Em ≈ 519 nm — standard FITC spectral profile, compatible with FITC/GFP filter sets and channels.
Degree of labeling
Typically 0.5–3 mol% FITC per polymer chain, grade-dependent. Custom labeling density available on request.
Free-dye removal
Purified by dialysis to remove unconjugated FITC — each COA reports residual free-dye content by UV-Vis.
Photostability
Standard FITC photobleaching kinetics apply — minimize light exposure during handling and imaging.
Exact quantum yield and per-batch spectral scans are provided with the Certificate of Analysis — see Documents below.
Base-polymer values for our standard PLLA grade. Request a batch-specific COA for labeling degree and spectral data on your order.
Base Polymer CAS | 33135-50-1 (unlabeled PLLA) |
|---|---|
| Label | Fluorescein isothiocyanate, CAS 27072-45-3 |
| Conjugation Site | Chain-end amine, thiourea linkage |
| Appearance | Pale yellow-green powder |
| Structure | Semi-crystalline (L-lactide homopolymer) |
| Melting Point (Tm) | 170–180 °C |
| Glass Transition (Tg) | ≈ 55–60 °C |
| Excitation / Emission | ≈ 495 nm / ≈ 519 nm |
| Degree of Labeling | 0.5–3 mol% FITC per chain, grade-dependent |
| Solubility | Soluble in chloroform, THF, dioxane; insoluble in water |
| Storage Conditions | -20 °C, sealed, desiccated, protected from light |
| Minimal Order Quantity | 1 g |
Need figures outside this range, or a certificate for a specific lot? Talk to technical sales →
Choose a grade by degradation timeline
Higher Mw grades degrade more slowly, extending the window over which fluorescence signal reflects intact polymer.
Mw 20,000–50,000
Low Mw
Faster clearance — shorter imaging studies, in vitro uptake assays.
Mw 50,000–100,000
Mid Mw
General-purpose grade for most scaffold and nanoparticle tracking work.
Mw 100,000–200,000
High Mw
Extended degradation window — long-term implant and in vivo imaging studies.
Applications
Scaffold visualization
Track scaffold architecture and cell infiltration over weeks-to-months tissue-engineering studies.
Implant tracking
Follow slow-degrading fixation devices and implants through extended in vivo imaging timelines.
Long-term biodistribution
Trace nanoparticle or microsphere clearance over multi-week to multi-month study windows.
Stereocomplex research
Pair with FITC-PDLA to study stereocomplex PLA formation and co-localization by dual-channel imaging.
FAQ
Most frequent questions and answers
No — as a conjugate, it’s identified by catalog number rather than a single CAS Registry Number. The base Poly(L-lactide) carries CAS 33135-50-1, and the FITC label carries CAS 27072-45-3.
No — FITC is covalently bonded to the polymer chain end via a stable thiourea linkage, not physically adsorbed, so it doesn’t leach out during handling or in aqueous media.
Signal persistence tracks polymer degradation, not dye stability alone — because PLLA is semi-crystalline and slow-degrading, signal typically remains detectable over weeks to months, longer than with PDLLA-based labels.
Yes — we offer the same PLLA backbone labeled with alternative fluorophores (e.g. Cy5, Cy7) for multi-channel or deeper-tissue imaging. Contact technical sales for available options.