PLGA Powder
Material: PLGA, Pdlg Polymer
Particle size: 300um
LA：GA: 50:50/75:25/65:35
Appearance: Light yellow
Minimal order quantity: 50 gram
Advance your biomedical innovations with our high-purity Poly(lactic-co-glycolic acid) (PLGA) powder, a leading biocompatible and biodegradable polymer trusted for the most demanding applications. Ideal for controlled drug delivery, tissue engineering, and absorbable medical devices, our PLGA offers exceptional control over therapeutic release profiles. By precisely tailoring the lactide-to-glycolide ratio and molecular weight, you can engineer degradation rates that span from weeks to months, ensuring a predictable, sustained release of your active pharmaceutical ingredients. As it degrades through simple hydrolysis, PLGA breaks down into lactic and glycolic acid—natural metabolites that are safely processed by the body, guaranteeing excellent biocompatibility and minimizing chronic inflammatory responses. This inherent safety and tunability make it the gold standard for developing advanced therapeutic systems.
Our PLGA powder is synthesized to the highest standards, ensuring low polydispersity and superior batch-to-batch consistency. This reliability is critical for achieving reproducible results, from early-stage research to large-scale cGMP manufacturing. Its excellent solubility in a wide range of common organic solvents makes it exceptionally versatile and easy to process into various forms, including nanoparticles, injectable microparticles, electrospun scaffolds for tissue regeneration, and solid implants. potential applications in medical and pharmaceutical industries.
As a foundational polymer used in numerous FDA-approved therapeutic products and devices, our PLGA provides a trusted and well-documented pathway to accelerate your product development timeline. Choose our PLGA powder to build your next breakthrough on a foundation of quality, performance, and clinical success.
FAQ
Most frequent questions and answers
Yes. PLGA degrades through hydrolysis into lactic acid and glycolic acid. Both are natural, non-toxic metabolites that are already present in the human body and are safely eliminated through the Krebs cycle. This excellent safety profile is a primary reason why PLGA is widely used in FDA-approved medical devices and drug delivery systems.
PLGA is readily soluble in a wide variety of common organic solvents, making it very easy to work with. Recommended solvents include dichloromethane (DCM), chloroform, acetone, ethyl acetate, and tetrahydrofuran (THF). Its solubility allows for straightforward processing into nanoparticles, microparticles, films, and electrospun fibers.
The acidic byproducts of PLGA degradation (lactic and glycolic acid) can create an acidic microenvironment within the polymer matrix. This can potentially degrade pH-sensitive drugs. To mitigate this, formulators often co-encapsulate basic, excipients (like magnesium carbonate or calcium hydroxide) to neutralize the acid and maintain the stability of the active agent.
To maintain its chemical integrity and prevent premature degradation from moisture, PLGA powder should be stored in a tightly sealed container in a dry environment at -20°C. Before opening, always allow the container to warm up to room temperature to avoid water condensation on the cold polymer.
Our standard-grade PLGA is intended for research and development purposes. However, we also offer cGMP-grade PLGA manufactured under controlled conditions suitable for clinical trials and commercial manufacturing. Please contact us directly to discuss your specific cGMP requirements.
PLGA is sensitive to heat and moisture, so autoclaving (steam sterilization) is not suitable as it will cause rapid degradation. The most common and recommended methods for sterilizing PLGA are gamma irradiation or ethylene oxide (EtO) treatment. Care must be taken to validate the sterilization process to ensure it does not significantly alter the polymer’s molecular weight or degradation properties.
The Polydispersity Index (PDI) is a measure of the distribution of molecular weights in a given polymer sample. A PDI value close to 1.0 indicates a very uniform polymer population where most chains are of similar length. A low PDI is highly desirable as it leads to more predictable and reproducible degradation and drug release profiles. Our PLGA features a low PDI, ensuring high consistency.
The glass transition temperature (Tg) is the temperature at which the polymer transitions from a rigid, glassy state to a more rubbery, flexible state. The Tg of PLGA is typically between 40-60°C, depending on its composition. It is a critical parameter for processing and storage. For example, during processes like spray drying or lyophilization, it is important to keep the temperature below the Tg to prevent particle aggregation. It also informs the stability of the final product during storage.
Yes, every batch of our PLGA powder is shipped with a detailed Certificate of Analysis (CoA). The CoA includes key quality specifications such as the exact lactide:glycolide ratio, inherent viscosity or molecular weight (Mw), PDI, and glass transition temperature (Tg), ensuring full transparency and traceability for your records.
Absolutely. We understand that standard, off-the-shelf products may not fit every unique application. We offer custom synthesis services to produce PLGA with specific molecular weights, L:G ratios, or end-group functionalities to meet your precise research and development needs. Please contact our technical team to discuss your requirements.