PLGA-FITC
Fluorescein-labeled Poly(lactide-co-glycolide) | Base polymer CAS 26780-50-7
FITC conjugated to PLGA — the most widely used biodegradable copolymer for sustained-release depot formulations. Available across the full range of lactide:glycolide ratios, so you can match label to degradation timeline precisely.
- 50:50 to 85:15 ratios, acid or ester end groups
Base CAS 26780-50-7
PLGA — FITC
Fluorescein-labeled Poly(lactide-co-glycolide)
Appearance: Pale yellow-green powder
Structure: Amorphous, no Tm
LA:GA Ratio: 50:50 to 85:15
Storage: -20 °C, dark, desiccated
ISO 9001:2015
Manufactured under certified quality management
4 Ratio Grades
50:50, 65:35, 75:25, 85:15 in stock
Batch-Level COA
Ratio, Mw and free-dye content per lot
Light-Safe Shipping
Amber, insulated packaging protects fluorescence
Base Polymer CAS
26780-50-7
Excitation / Emission
495 / 519 nm
LA:GA Ratios
50:50 – 85:15
Degradation
Weeks – months
MOQ
1 g
Fluorescence parameters
These values are what most researchers check first — they determine whether this label works with your imaging setup and dosing.
Excitation / Emission
Ex ≈ 495 nm / Em ≈ 519 nm — standard FITC spectral profile, compatible with FITC/GFP filter sets and channels.
Degree of labeling
Typically 0.5–3 mol% FITC per polymer chain, grade-dependent. Custom labeling density available on request.
Free-dye removal
Purified by dialysis to remove unconjugated FITC — each COA reports residual free-dye content by UV-Vis.
Photostability
Standard FITC photobleaching kinetics apply — minimize light exposure during handling and imaging.
Exact quantum yield and per-batch spectral scans are provided with the Certificate of Analysis — see Documents below.
Base-polymer values common across our PLGA-FITC grades. Request a batch-specific COA for ratio and labeling data on your order.
Base Polymer CAS | 26780-50-7 (unlabeled PLGA, ratio-dependent) |
|---|---|
| Label | Fluorescein isothiocyanate, CAS 27072-45-3 |
| Conjugation Site | Chain-end amine, thiourea linkage |
| Appearance | Pale yellow-green powder |
| Structure | Amorphous — random lactide/glycolide copolymer, no Tm |
| Glass Transition (Tg) | ≈ 40–55 °C, ratio-dependent |
| Excitation / Emission | ≈ 495 nm / ≈ 519 nm |
| Degree of Labeling | 0.5–3 mol% FITC per chain, grade-dependent |
| End Groups | Acid or ester — selectable at order |
| Solubility | Soluble in chloroform, THF, ethyl acetate; insoluble in water |
| Storage Conditions | -20 °C, sealed, desiccated, protected from light |
| Minimal Order Quantity | 25 mg |
Need figures outside this range, or a certificate for a specific lot? Talk to technical sales →
Choose your ratio by degradation timeline
More glycolide means faster, more hydrophilic degradation. This is the main lever for tuning how long your fluorescence signal lasts.
Ratio: 50:50
Degradation: 1-2 months
Best for: Short-window microsphere release, rapid-clearance nanoparticle studies
Ratio: 65:35
Degradation: 2-4 months
Best for: General-purpose microspheres and nanoparticle tracking
Ratio: 75:25
Degradation: 4-6 months
Best for: Extended sustained-release depot formulations
Ratio: 85:15
Degradation: 6+ months
Best for: Long-term implant and scaffold tracking
Applications
Tissue engineering scaffolds
Confirm scaffold degradation and cell infiltration timing in bone and soft-tissue repair studies.
Vaccine & peptide delivery
Track particle-based delivery vehicles for peptides, proteins, and vaccine antigens.
Nanoparticle biodistribution
Track PLGA nanoparticle uptake and clearance across a wide range of tunable timelines.
Sustained-release microspheres
Visualize the classic depot-formulation microsphere — the most established PLGA drug-delivery application.
FAQ
Most frequent questions and answers
Higher glycolide content (e.g. 50:50) degrades fastest and suits short-window studies; higher lactide content (e.g. 85:15) degrades slowest and suits long-term implant or scaffold tracking. See the ratio table above for guidance.
PDLLA is a lactide-only homopolymer; PLGA copolymerizes lactide with glycolide, which degrades faster and more hydrophilically. PLGA also gives you a wider, more finely tunable range of degradation rates through the LA:GA ratio.
No — as a conjugate, it’s identified by catalog number rather than a single CAS Registry Number. The base PLGA polymer is commonly referenced under CAS 26780-50-7, though exact CAS can vary by ratio and end group across suppliers; the FITC label carries CAS 27072-45-3.
Acid-terminated grades are easier to conjugate further or tend to degrade slightly faster due to autocatalysis; ester-terminated (capped) grades are more hydrolytically stable, useful for longer shelf life.