How Long Does It Take for Lactide to Degrade?

Lactide, a cyclic diester derived from lactic acid, is a key building block in the production of biodegradable polymers such as polylactic acid (PLA) and Poly(lactic-co-glycolic-acid). These polymers have gained significant attention due to their eco-friendly nature and potential applications in various industries.

One crucial aspect of biodegradable polymers is their degradation time, particularly the degradation of lactide itself. In this article, we will delve into the factors that influence the degradation of lactide and explore how long it typically takes for lactide to degrade.

Table of Contents

Understanding Lactide Degradation

Lactide degradation refers to the breakdown of the lactide molecule into simpler compounds. This process can occur through various mechanisms, including hydrolysis, enzymatic degradation, and microbial action.

The degradation of lactide ultimately leads to the formation of lactic acid, which can be further metabolized by microorganisms in the environment.

Factors Affecting Lactide Degradation

Several factors influence the degradation process of lactide, and each one contributes to the overall timeline. Let’s explore these factors in detail:


The rate of lactide degradation is highly dependent on temperature. Higher temperatures accelerate the process, while lower temperatures slow it down. This information is important when considering the disposal of PLA products in different environments.


Moisture levels play a significant role in lactide degradation. Increased moisture can enhance hydrolysis, a common mechanism for lactide breakdown. However, extreme moisture levels can also impede degradation, requiring a delicate balance in environmental conditions.

pH Levels

The pH of the surrounding environment affects lactide degradation. Acidic conditions, such as those found in landfills, can expedite the process. On the other hand, alkaline environments may slow down degradation, necessitating tailored disposal methods.

Surface Area

The surface area of the material impacts the degradation rate. Smaller particles or increased surface exposure result in faster degradation due to enhanced contact with the degrading agents.


Certain catalysts can accelerate the degradation of lactide. These catalysts act as initiators, breaking down the lactide molecule and expediting the degradation process.

Stereocomplex Formation

Lactide is available in three enantiomeric forms: L-lactide, D -lactide and DL-Lactide. When these forms are combined to form a stereocomplex, the resulting polymer exhibits enhanced thermal and mechanical properties. Stereocomplex formation can also influence the degradation behavior of lactide-based polymers, potentially slowing down the degradation process.

Lactide Degradation Pathways

Lactide Degradation

Lactide can undergo various degradation pathways, with the specific pathway depending on environmental conditions and the presence of catalysts. Here are the three primary pathways:


Hydrolysis is the most common degradation pathway for lactide. In the presence of water, lactide molecules react with hydroxyl ions, leading to the formation of lactic acid. This process involves breaking the ester bonds in lactide, resulting in the release of lactic acid monomers.


Lactide can also be degraded by microorganisms, such as bacteria and fungi. These organisms produce enzymes that break down the lactide polymer into simpler compounds, ultimately converting it into carbon dioxide, water, and biomass.

Chemical Degradation

Under certain conditions, lactide can undergo chemical degradation processes such as thermal decomposition, photodegradation, and oxidation. These pathways involve the breakdown of lactide through non-biological reactions, often triggered by heat, light, or reactive chemical species.

Degradation Time of Lactide

The degradation time of lactide can vary depending on the specific environmental conditions and the composition of the polymer matrix. However, we can provide a general overview of the degradation time based on typical scenarios.

In Natural Environments

In natural environments such as forests, bodies of water, or open land, lactide degradation can take several months to years. The presence of moisture, ambient temperature, and microbial activity contribute to the breakdown of lactide over an extended period.

In Industrial Composting Facilities

In controlled industrial composting facilities, where conditions are optimized for biodegradation, lactide can degrade within a matter of weeks to months. The higher temperatures and increased microbial activity in these facilities accelerate the degradation process.

In Soil and Landfills

Lactide-based polymers, when disposed of in soil or landfills, generally degrade at a slower rate compared to natural environments or composting facilities. The lack of optimal conditions and limited access to moisture and microorganisms can significantly prolong the degradation time. In such cases, it may take several years or even decades for complete degradation to occur.


lactide degradation is a complex process influenced by various factors, including temperature, moisture, pH levels, surface area, catalysts, and polymer structure.

By understanding the degradation pathways and environmental implications, we can make informed decisions regarding the disposal and management of PLA products.